CTSG and cancer: At 2.5 μg/mL, > 60% inhibition of cancer cells (A549, HA59T, HeLa, HT1080, U937) after 24 h incubationAt 2 μg/mL, > 90% inhibition of colony formation (A549 and HeLa)Act like lytic peptides, membrane disruption in HT1080 cells after 1-h incubationGranulation in cytoplasmic space of HT1080 cells, downregulation of necrosis-related genes (calpain 5 and cathepsin G), suggesting triggers anti-necrosis through cell membrane lytic effect