TLR2-dependent uptake involves the recognition of fungal carbohydrates, but several studies exploring its role in different models of fungal infections showed conflicting results, suggesting both protective and non-protective effects, which could be explained by differences in the virulence of pathogens, the antigens, and the genetic background of the animals used (Oliveira-Nascimento et al., 2012), and also in differences between animal vs. human studies. This evidence concerns the gene TLR2 and fungal infectious disease.