Age of onset (OR 1.03, 95% CI 1.00–1.12, P = 0.024), AQP4 status (OR 1.44, 95% CI 1.02–2.04, P = 0.037), diabetes (OR 3.97, 95% CI 1.20–13.09, P = 0.049), statin treatment (OR 2.64, 95% CI 1.05–6.06, P = 0.04) initial EDSS (OR 1.59, 95% CI 1.29–1.90, P = 0.001), and relapses (OR 2.21, 95% CI, 1.17–4.18, P = 0.023) were significantly associated with outcomes in patients. The gene discussed is AQP4; the disease is diabetes mellitus.