GRIN2D and schizophrenia: It is possible that acute blockade of NMDARs by NMDAR antagonists such as ketamine causes schizophrenia-related symptoms by preferentially reducing the activity of neurons that express NMDARs containing GluN2D (SST interneurons, dopamine neurons) and GluN2C (thalamic relay cells, PV-positive cells of the thalamic RTN and cortex, and presynaptic terminals of PV interneurons).