NRG2 and schizophrenia: Neuregulin 2 expression is, however, reduced in schizophrenia patients (36), and Nrg2 knockout in mice leads to a wide range of schizophrenia-related and partly clozapine-responsive deficits (reduced prefrontal dopamine, novelty- and amphetamine-induced hyperlocomotion, and impairments of T-maze working memory, sociability, and pre-pulse inhibition) (39).