GRIN2B and schizophrenia: For instance, pharmacological GluN2B blockade does not affect pre-pulse inhibition and may increase motivation, working memory, processing speed, sustained attention, and also motor impulsivity (23, 24, 26–29)—note, however, that these pharmacological results can contrast strongly with the schizophrenia-related deficits seen with cell type–specific Grin2B-ablation in mice (see below).