GRIN2B and schizophrenia: Further, pharmacological blockade of GluN2B alone is sufficient to cause behavioral abnormalities in rodents, in particular increased locomotor activity, which has been likened to psychosis (23, 24), as well as reduced cognitive flexibility (25), but does not recapitulate the entire profile of schizophrenia, at least as far as the disease can be modeled in rodents.