Most importantly, two studies from the Nakazawa lab have shown directly that NMDAR ablation which is stochastically delayed by using the 12-kB-long inter-loxP distance responder line does not lead to a schizophrenia-related phenotype even when combined with long-term social isolation (see Table 1), while ablation of GluN1 at an earlier time point using the 2.1 kB inter-loxP distance responder line does (40, 173). The gene discussed is GRIN1; the disease is schizophrenia.