To that end, we sought to test whether autonomic control of blood pressure (BP) and heart rate (HR) differed between wild-type and TASK−/− mice, to test whether the arterial baroreflex function was impaired in TASK−/− mice, and to test whether the activation of MR was required for dysautonomia and dysfunctional baroreflex in TASK−/− mice. The gene discussed is NR3C2; the disease is dysautonomia.