It was well documented that hepatic lipid accumulation was closely related to the induction of SREBP1 expression (Pai et al., 2013) and AMPK/SREBP pathway had critical functions in the development of MLD (Kohjima et al., 2008; Jung et al., 2011; Li et al., 2011). This evidence concerns the gene SREBF1 and metachromatic leukodystrophy.