Fibromodulin (FMOD) is a small leucine-rich proteoglycan ECM protein, and is a member of a family of secreted proteoglycans that play important roles in signaling, collagen fibrillogenesis, cell migration, adhesion, growth, differentiation, and apoptosis (Pietraszek-Gremplewicz et al., 2019), while individual members have different functions and effects on cancer (Iozzo and Sanderson, 2011; Edwards, 2012). Here, FMOD is linked to cancer.