FMOD and cancer: Significantly, our results for the first time add the ECM component FMOD to the list of target genes of the Wnt/β-catenin pathway, where FMOD-mediated ERK activation is a path through which Wnt/β-catenin signaling facilitates cancer metastasis, thus linking Wnt/β-catenin signaling to the ECM, to ERK and to cancer metastasis.