HDAC6 and breast carcinoma: Furthermore, Aspirin inhibits breast cancer metastasis by suppressing FMOD expression mediated by the Wnt/β-catenin pathway, in which Aspirin suppresses FMOD transcription by attenuating the Wnt/β-catenin pathway, via inhibiting HDAC6 deacetylation of β-catenin to promote β-catenin phosphorylation, ubiquitination and cytoplasmic degradation.