GSK3B and breast cancer: Interestingly, when treated with 10 mM lithium chloride (LiCl), an inhibitor of GSK-3β and activator of the Wnt/β-catenin signaling pathway (Dihlmann et al., 2003; Jansson et al., 2005), both human (Figures 1A, B) and mouse (Figures 1C, D) mammary tumor cells displayed a marked increase in migration and invasion ability; and in the treatments combining LiCl and Aspirin, the inhibitory effect of Aspirin largely remained while overriding the enhancement by LiCl.