These animal model studies and patient clinical data analyses further support our in vitro results that illustrate the relationships in breast cancer between FMOD, β-catenin and Aspirin through the Wnt/β-catenin signaling pathway, and establish physiol-pathological significance of the regulation of FMOD expression by the Wnt/β-catenin pathway and the effects of Aspirin in the intervention of BCCMI. Here, FMOD is linked to breast carcinoma.