In colon cancer, Aspirin has been reported to inhibit the canonical Wnt/β-catenin signaling pathway by inducing β-catenin phosphorylation (Dihlmann et al., 2003; Bos et al., 2006) resulting in the downregulation of nuclear β-catenin and TCF4 signaling. The gene discussed is TCF4; the disease is malignant colon neoplasm.