As a secreted protein, Cyr61 connects with the extracellular matrix and the cell surface (Grzeszkiewicz et al., 2002) and is a communication media between cancer cells and the host which can reflect the changes arising due to cancer treatment (Bonin-Debs et al., 2004; Mbeunkui et al., 2006). The gene discussed is CCN1; the disease is cancer.