Conversely, a recent study performed by Van Duijn J et al. showed that in a mouse model of advanced atherosclerosis (high fat diet-fed LDLR−/− mice), depletion of CD8 increased the Th1 CD4+ T cell fraction in lesions, resulting in increased inflammation and lesion destabilization (van Duijn et al., 2019). Here, LDLR is linked to atherosclerosis.