Indeed, Kyaw et al. showed that CD8+ T cell depletion using a CD8α or CD8β monoclonal antibody ameliorated atherosclerosis in ApoE−/− deficient mice fed a high-fat diet by reducing lipid and macrophage accumulation, apoptosis, necrotic cores, and inflammatory cytokines such as MCP-1, IL-1β, and interferon γ (IFN-γ). Here, APOE is linked to atherosclerosis.