In CNS tissue, increased expression of ICAM-1 was described in both the gray and white matter of the ACC in bipolar patients compared with controls (gray: p = .001; white: p < .001) and schizophrenia patients (gray: p = .016; white: p = .025), and modestly increased expression was described in the white matter of the ACC in bipolar patients compared with patients with unipolar depression (p = .049). The gene discussed is ICAM1; the disease is major depressive disorder.