These results, combined with the reduction in insoluble Aβ plaques, indicate that pharmacological restoration of mitophagy in microglia increases its phagocytic activity and mitigates NLRP3-dependent neuroinflammation in AD models, thus ameliorating AD pathology (Fang et al., 2019; Lautrup et al., 2019). Here, NLRP3 is linked to Alzheimer disease.