In a recent study, administration of NMN also showed similar cognitive improvement and AD pathology inhibition in APP/PS1 and 3xTgAD mouse models and in C. elegans models, and this was shown to be mediated via mitophagy induction (Fang, 2019; Fang et al., 2019; Lou et al., 2019). The gene discussed is APP; the disease is Alzheimer disease.