PRKN and Alzheimer disease: The parkin-mediated Aβ clearance was also associated with reduced oxidative stress, restored mitochondrial function, improved efficiency of the TCA (tricarboxylic acid) cycle, increased glutamate synthesis, and a re-established neurotransmitter equilibrium, thus making it a prospective candidate for gene therapy against AD pathology (Khandelwal et al., 2011).