The protective role of UA in AD through mitophagy seems to be conserved across species, as an APP/PS1 transgenic mouse model also showed improved learning and memory retention along with a reduction in levels of amyloid peptides Aβ42, Aβ40 and extracellular Aβ plaques with UA treatment (Fang et al., 2019). Here, PSEN1 is linked to Alzheimer disease.