SARM1 and Alzheimer disease: As NAD+ acts as a cofactor for multiple proteins, such as sirtuins (SIRT 1-7), PARP (poly [ADP-ribose] polymerase), CD38, and SARM1 (sterile alpha and TIR motif-containing 1), all having an important role in the regulation of the autophagy/mitophagy pathway, mitophagy induction using NAD+ precursors can be a promising therapeutic approach for treating AD pathology (Maynard et al., 2015; Fang, 2019).