The role of kinases and phosphatases, namely, GSK3β and PP2A, has also been implicated in ROS production and tau hyperphosphorylation (Abou-Sleiman et al., 2006; King et al., 2008; Feng et al., 2013), thus substantiating the primary mitochondrial cascade hypothesis in the development of AD. This evidence concerns the gene MAPT and Alzheimer disease.