PRKN and neuroblastoma: In human neuroblastoma SH-SY5Y cells, UA treatment increased the levels of a set of mitophagy-related proteins such as parkin, full-length PINK1 (F-PINK1), p-ULK1 (Ser 555), BECN1, AMBRA1, and Bcl2L13, leading to mitophagy induction.