A recent study by Fang et al. (2019), showed that the levels of mitophagy-related proteins Bcl2L13, PINK1, and BNIP3L/NIX were reduced and mitophagy initiation proteins such as phospho-ULK1 (Ser555), and phospho-TBK1 (Ser172) were inactivated in AD patient samples. This evidence concerns the gene PINK1 and Alzheimer disease.