MAPT and neuroblastoma: This was attributed to the inhibition of glutathione synthesis using buthionine sulfoximine (BSO), which caused a significant increase in the activity of kinases like JNK and p38 and a decrease in the activity of phosphatases such as PP2A, thus leading to hyperphosphorylation of tau in M17 neuroblastoma cells in a time-dependent manner (Su et al., 2010).