A few studies have highlighted the phosphoinositide 3 kinase – Akt – mammalian target of rapamycin (PI3k-Akt-mTor, PAM) pathway (Liu T. et al., 2013; Majd et al., 2019) as a possible common mechanism that may be the link in the inverse relation between AD and cancer in general. The gene discussed is MTOR; the disease is cancer.