As discussed below, tumor antigens originating from the intracranial tumor may reach tumor-draining LNs insufficiently to induce substantial T cell priming, and therefore, efficient generation of anti-tumor immune responses against tumors in the brain may rely on T cell priming and the release of tumor antigen-specific T cells from CTLA-4 blockade within the extracranial tumor-draining LNs. The gene discussed is CTLA4; the disease is neoplasm.