While the cause of AD is still not completely clear (Davis et al., 2018; Shi and Holtzman, 2018; Henstridge et al., 2019), AD is hallmarked by the accumulation of protein aggregates, most notably plaques between neurons, rich in β-amyloid (Aβ), and intraneuronal tangles, composed mainly of tau protein. This evidence concerns the gene MAPT and Alzheimer disease.