In men, a higher risk of ischemic stroke was found in Q4 group of cg02494239 methylation in ABCG1 compared with Q1 group (OR = 6.654, 95% CI 1.094–40.476, P = 0.040) (Table 2 and Additional file 1: Table S3). The gene discussed is ABCG1; the disease is ischemic stroke.