ZBTB7A and cancer: Other targets of LRF/ZBTB7A-mediated regulation of oncogenesis include Striatin 4 (STRN4), a protein implicated in the progression of various human cancers [50, 75] and protein C-ets-1 (ETS-1), which is overexpressed in several cancers and implicated in cell proliferation, apoptosis, invasion, and migration [61].