Potential mechanisms involve the LRF/ZBTB7A-mediated transcriptional activation of myocyte enhancer factor 2D (MEF2D), an oncogene favoring the invasion of hepatocellular carcinoma cells [46, 47], and independently, the activation in ovarian cancer of membrane type 1-matrix metalloproteinase (MT1-MMP), a molecule playing a vital role in the dissociation of the extracellular matrix and the consequent dissemination of tumor cells [51]. Here, ZBTB7A is linked to neoplasm.