In human hepatocellular carcinoma cell lines, LRF/ZBTB7A regulates cell cycle progression by either suppressing or promoting the expression of key cell cycle regulators like cyclin-dependent kinase inhibitors 2B, 1B, and 1A (p15, p27, and p21 genes, respectively), tumor protein p53 (TP53), CYCLIN D1, CYCLIN D3, and cyclin-dependent kinases CDK4 and CDK6. This evidence concerns the gene CDKN2B and hepatocellular carcinoma.