Finally, the chromosomal region 19p13.3, encompassing the LRF/ZBTB7A, is frequently lost in human cancers, as presented in the Cancer Genome Atlas database (PMID: 22901813), while somatic loss-of-function zinc finger mutations of LRF/ZBTB7A present another mechanism promoting cancer progression [104]. The gene discussed is ZBTB7A; the disease is cancer.