Lrf/Zbtb7a was also shown to interact with and antagonize the transcriptional activity of Sry-related HMG box 9 (Sox9), which drives expression of several genes contributing to increased proliferation and oncogenesis, and that loss of Lrf/Zbtb7a bypasses cellular senescence and promotes invasion in Pten-null prostate cancers [88, 89]. Here, ZBTB7A is linked to Familial prostate cancer.