In order to explore the effect of lncRNA PAXIP1-AS1 on the biological characteristics of glioma cells, oe-NC + sh-NC, oe-PAXIP1-AS1 + sh-NC, oe-PAXIP1-AS1 + sh-ETS1 and oe-PAXIP1-AS1 + sh-KIF14 were delivered to TJ905 cells and effects on migration, invasion and angiogenesis of glioma cells were examined. This evidence concerns the gene PAXIP1 and central nervous system cancer.