A previous transcriptomic analysis, accompanied by functional assays, has provided evidence demonstrating a regulatory role for lncRNA PAXIP1-AS1 in idiopathic pulmonary arterial hypertension by controlling the proliferative and migratory potential of smooth muscle cells by modulating the downstream target paxillin [29]. The gene discussed is PAXIP1; the disease is idiopathic pulmonary arterial hypertension.