The results obtained indicated that at 0 W, compared with mice in the control and VDR−/− groups, the IL-4, IL-10, IL-17 and INF-γ levels of SLE mice (in the SLE, SLE + VD3, and SLE + VD3 + VDRinsert groups) were significantly increased (p < 0.05). The gene discussed is IL4; the disease is systemic lupus erythematosus.