Based on the ELISA results, before treatment (0 W), the levels of anti-nRNP IgG and anti-dsDNA IgG in SLE mice (in the SLE, SLE + VD3, SLE + VD3 + VDRinsert groups) were profoundly upregulated compared with the levels in the control and VDR−/− groups (p < 0.05). Here, VDR is linked to systemic lupus erythematosus.