RT-qPCR and western blot analysis that before treatment (0 W), the mRNA expression of Skp2 in SLE mice (in the SLE, SLE + VD3 and SLE + VD3 + VDRinsert groups) was significantly increased, while the expression of p27 decreased compared with expression in control mice (p < 0.05). The gene discussed is SKP2; the disease is systemic lupus erythematosus.