Flow cytometry analysis showed that the numbers of T helper cells (Th17, Th1, Th2) and CD4−CD8− DN cells were significantly increased in the SLE mice (in the SLE, SLE + VD3, SLE + VD3 + VDRinsert groups) when compared with numbers in the control and VDR−/− groups, while the number of Tregs was reduced (p < 0.05). Here, VDR is linked to systemic lupus erythematosus.