To determine the mechanism underlying the role of FOXO1 in tumorigenesis, we focused on the correlation between FOXO1 and PAX3 in EOC, since PAX3-FOXO1 is a well-known fusion protein that is associated with alveolar rhabdomyosarcoma and modulates multiple signaling pathways involved in cell proliferation, migration, and death. This evidence concerns the gene FOXO1 and rhabdomyosarcoma.