A separate study of 398 women with PCOS combining FET and the GnRH-ant protocol determined that overweight/obese patients (BMI ≥ 24 kg/m2) exhibited significantly decreased rates of implantation, live birth, and birth of twins relative to normal weight controls, whereas rates of late abortion were significantly increased in these individuals with a higher BMI. Here, GNRH1 is linked to polycystic ovary syndrome.