GNRH1 and polycystic ovary syndrome: For example, Akpinar found that in a study of 193 women with PCOS undergoing ovarian stimulation via the mid-luteal long GnRH agonist or flexible GnRH antagonist protocols in a fresh embryo transfer cycle, being obese or overweight had no effect on the implantation, clinical pregnancy, ongoing pregnancy, or miscarriage rates [30].