Acting as one of the most important EGFR bypass signaling pathways, IGF-1R signaling has been demonstrated to regulate essentially the EGFR-TKIs resistance in NSCLC [5, 8], the current study was designed to elucidate whether changes in miR-762 expression levels correlate to the development of resistance to gefitinib, and to further identify the putative targets of miR-762 using in vitro cell-based systems. Here, EGFR is linked to non-small cell lung carcinoma.