TRIM21 has been shown to decrease the response to cisplatin in colon cancer and PC by downregulating Par‐4 expression, whereas high‐level TRIM21 expression was correlated with poor OS in PC patients.24 Based on these findings, we further demonstrated that these three genes were more highly expressed in PC tissues than in corresponding normal tissues and that high RRM1 and TRIM21 expression indicated poor prognosis in PC patients. Here, TRIM21 is linked to malignant colon neoplasm.