High expression of EGFR occurs in more than 90% of HNSCCs.4, 5 The activation of the EGFR signaling pathway is associated with a cancer cell phenotype, inhibition of apoptosis, established angiogenesis, and increased metastatic potential.6 It is worth noting that a retrospective study including 47 confirmed HNSCC patients revealed that 57% of patients harbored EGFR‐TK domain mutations.7 EGFR regulates a specific population in HNSCC, which presents stem cell‐like properties.8 These facts indicated a possible link between HNSCC stemness and highly activated EGFR signaling. This evidence concerns the gene TKT and head and neck squamous cell carcinoma.