Acromegaly is a disease characterized by growth hormone (GH) hypersecretion, usually due to a pituitary adenoma, which causes disproportionate skeletal, soft tissue, and organ growth, resulting in multisystem-associated comorbidities, including hypertension, diabetes, sleep apnea, arthropathy, and increased mortality [1, 2]. This evidence concerns the gene GH1 and diabetes mellitus.