Furthermore, along with interferon γ, interleukin-1, and other cytokines, the pro-inflammatory burst in HLH includes tumor necrosis factor (TNF), which is a potent inhibitor of lipoprotein lipase and stimulator of hepatic lipogenesis, and may be responsible for the frequently observed hypertriglyceridemia [9]. This evidence concerns the gene TNF and hypertriglyceridemia.