Approximately half of the hits with “proproliferative” effect (9/17 enzymes, average normalized proliferation of all shRNAs per target) were histone methyltransferases such as EED [26], and DNA methyltransferase 1 (DNMT1), both had been shown to correlate with PCa aggressiveness [26]. The gene discussed is PRDM9; the disease is posterior cortical atrophy.