Immune deviation from a T2-high asthma to a T2-low asthma/T1 endotype is characterized by biomarkers of neutrophil recruitment e.g., IL-1alpha, IL-6, IL-843, innate immune response dysregulation e.g., IL-23, TNF alpha, interferon, IL-1744–48, and includes neutrophilic noneosinophilic asthma49. This evidence concerns the gene TNF and asthma.