We previously showed that a JmjC histone demethylase, lysine-demethylase 2 A (KDM2A), decreases the dimethylated lysine 36 of histone H3 (H3K36me2) in the ribosome RNA gene (rDNA) promoter and represses rRNA transcription under starvation in breast cancer cells28,29. This evidence concerns the gene KDM2A and breast cancer.