The six SNVs revealed by the MLR model tests (rs11701674, rs28412810, rs11700591, rs62237637, rs11702319) were all linked and resided within intronic regions of the Down Syndrome cell adhesion molecule (DSCAM) gene), which encodes an immunoglobulin superfamily member, is involved in axon guidance and is a candidate for Down syndrome and congenital heart disease40. This evidence concerns the gene DSCAM and Down syndrome.