AQP2 and cyst: However, in compartments where multiple cysts comprised more than 30% of the area (Fig. 1f, the compartments surrounded by dotted lines), most of these cysts were AQP2 positive, similar to those in severe-type kidneys (Fig. 4f, Supplementary Fig. 6b), suggesting that cyst formation in AQP2-positive segments is more severe than in other segments.