Likewise, leptin has been implicated in the pathogenesis of intestinal inflammation in Crohn’s disease (CD), in which hyperplastic mesenteric fat (“creeping fat”) wraps inflamed small intestinal segments4, and acts as a source of leptin and additional adipokines, that can modulate both systemic immune cell composition, as well as intestinal epithelial cell function in animal models of colitis5. Here, LEP is linked to Cowden disease.