However, we are convinced that our results still provide valuable insights regarding the immune-stimulatory potential of leptin in human intestinal inflammation, which are supported by observations in mice as leptin-deficient ob/ob mice are protected from DSS-induced colitis6 and the pharmacologic inhibition of the leptin receptor attenuates disease severity in Il10−/− mouse models of colitis7. The gene discussed is LEPR; the disease is inflammation.