In contrast, we found a severe reduction of CD14+ monocytes (G6) and of Tbet+CD56+CD8+ (G4) and Tbet+CD56+CD8− NK cells (G5) in the AGLCD patient but not in CD patients or healthy donors (Fig. 1e, f), suggesting that these alterations are lipodystrophy-specific and at least partially caused by leptin deficiency as leptin receptor-deficient db/db mice also show decreased frequencies of NK cells22. Here, LEP is linked to Cowden disease.