Using TCGA and SU2C datasets of 492 and 150 PCa adenocarcinomas and metastasis, respectively, we for the first time show that hemizygous deletion of PPP2R2A is associated with poor tumor prognosis, and that the frequency of hemizygous deletion increases with tumor stage and is maximal in metastatic PCa. The gene discussed is PPP2R2A; the disease is posterior cortical atrophy.