To develop models for functional analysis, we assessed DU145, LNCaP, C4-2, and 22RV1 PCa cell lines for PPP2R2A expression and compared it to those with defined PPP2R2A genotypes, including normal BJ fibroblasts (wt), PC3 (shallow deletion/hemizygous loss), and VCaP cells (deep deletion/homozygous loss) (Fig. 2a, Suppl. The gene discussed is PPP2R2A; the disease is posterior cortical atrophy.