TP53 and cancer: Importantly, Neat1 is controlled by the p53 pathway, but cancer progression is enhanced or inhibited in a context-dependent manner: The lack of Neat1 enhanced the development of premalignant pancreatic intraepithelial neoplasias in KrasG12D-expressing mice (Mello et al. 2017), whereas the progression of skin neoplasias induced by carcinogens was suppressed in Neat1 KO mice (Adriaens et al. 2016).