Intriguingly, one prior study expressing soluble CX3CL1 via adenoviral transformation in a Tg4510 model of tauopathy was shown to reduce tau pathology (Nash et al., 2013), and CX3CR1 deficiency to impair microglia to internalize tau aggregates (Bolós et al., 2017). This evidence concerns the gene CX3CR1 and tauopathy.