Analysis of tumor lysates from control(M1, M2) and arsenic sulfide-treated(M3, M4) mice showed an obvious decrease in the expression of NFATc3 proteins (Fig. 7d), and there was a significant increase in RAG1 and γ-H2AX protein levels in the tumors from mice treated with arsenic sulfide (Fig. 7d). Here, H2AX is linked to neoplasm.