In previous studies, the risk factors associated with this upstaging such as young age, palpability, nipple discharge, specimen number, extent of microcalcification, mass size, high nuclear grade, axillary lymph node involvement, multicentric lesion, contralateral lesion, and the presence of HER-2 over expression, were reported as predictors of DCIS with IC prior to surgery [1, 4–11, 15–28]. The gene discussed is ERBB2; the disease is ductal breast carcinoma in situ.