Low DUSP5 expression was found in different types of tumors and can influence the prognosis of tumor patients by promoting tumor growth, invasion and metastasis.29, 30, 31 Yan et al. and Cai et al. both clarified that DUSP5 expression was negatively associated with advanced pathological stage in colorectal cancer and prostate cancer.32, 33 In pancreatic cancer cells, DUSP5 inhibited cell growth in a dose dependent manner.34 Nevertheless, the specific role of DUSP5 in the control of FTC metastasis which further contributes to poor prognosis has not yet been clearly elucidated. This evidence concerns the gene DUSP5 and colorectal cancer.