Additionally, TGFβ is one of target genes of signal transducer and activator of transcription 3 (STAT3)7 that promotes hepatic fibrosis through increasing TGFβ expression in mice with liver fibrosis.8 Also, rapid early activation of STAT3 has been observed in HSCs and fibroblasts but not in normal hepatocytes,9 indicating that STAT3 might be a therapeutic target for liver fibrosis. This evidence concerns the gene STAT3 and Hepatic fibrosis.