As treatment of amlexanox attenuated the progression of liver fibrosis based on above results, we then investigated the roles of TBK1 and IKKε in fibrosis regression by feeding a DDC diet for 4 weeks, followed by feeding a chow diet plus amlexanox (50 mg/kg) for 1, 2 and 3 weeks (RES group; total 5, 6 and 7 weeks, respectively). The gene discussed is TBK1; the disease is Hepatic fibrosis.