MELK and neoplasm: Several studies have reported that MELK acts as an oncogene in many kinds of tumours from multiple systems.33, 34, 35, 36, 37, 38 In this study, we confirmed the oncogenic role of MELK in bladder tumorigenesis and elucidated for the first time the regulatory mechanism of MELK inhibition in BCa cells by bioinformatics analysis as well as in vitro/ in vivo investigation.