This strongly suggests that, by blocking BRD4, BET inhibition can regulate the PI3K signal in cancer cells.23 However, in xenograft models of endometrial cancer, JQ1 significantly increases the expression of PTEN, favouring the block of the PI3K/AKT signalling pathway.24 Very recently it was demonstrated that BRD4 inhibition induces apoptosis and growth arrest in glioblastoma cells via VEGF/PI3K/AKT regulation.25 Furthermore, JQ1 is also effective to reduce the levels of p‐Erk 1/2 in mouse models of pancreatic cancer and in anaplastic thyroid cancer cells where is often over‐activated. This evidence concerns the gene PTEN and thyroid gland undifferentiated (anaplastic) carcinoma.