Cerrato et al reported a heterozygous KISS1R mutation (c.A1079T/p.H360L) in a male IHH patient who had no pubertal development.19 Teles et al reported a heterozygous KISS1R variant (p.E252Q) in a male patient with sporadic normosmic IHH, who exhibited micropenis and cryptorchidism at birth, and no pubertal development.20 These studies indicated that heterozygous mutations in KISS1R could be also involved in the pathogenesis of IHH. This evidence concerns the gene KISS1R and Micropenis.