This finding has since been successfully applied in clinical practice.11 PIVKA‐II combined with Golgi protein 73 (GP73) showed higher accuracy than AFP in early HCC diagnosis.12 PIVKA‐II has been included in markers for auxiliary diagnosis of HCC in the Standardization of Diagnosis and Treatment for Hepatocellular Carcinoma (2011 Edition) issued by National Health Commission of the People's Republic of China. This evidence concerns the gene AFP and hepatocellular carcinoma.