AFP and hepatocellular carcinoma: The previous studies have shown that PIVKA‐II is helpful for the diagnosis of HCC.1, 16 Moreover, several studies have shown that AFP‐L3 could improve the detection rate of HCC when it is combined with PIVKA‐II.17, 18 Lim et al18 also suggest that combining AFP, AFP‐L3, and PIVKA‐II improves the diagnostic accuracy for HCC among cirrhotic patients compared with using each marker individually.