Investigating HIF-1α-status in both BC1 and BC2 showed that patients with two HIF-1α-negative tumors had the lowest BCM and those with HIF-1α-positive BC2 the highest (Fig 4) (Cox-regression: BC1 HIF1-BC2HIF1- reference, BC1HIF1+BC2HIF1- HR 1.4 95%CI 0.91–2.3 p = 0.1, BC1HIF1-BC2HIF1+ HR 1.9 95%CI 1.3–2.6 p<0.001, BC1HIF1+BC2 HIF1+ HR 1.7 95%CI 0.83–3.5 p = 0.1). The gene discussed is HIF1A; the disease is blue cone monochromacy.