The gene expression of 15 genes with AUCs ≥0.80 (IL7R, CD3E, IL5, NLRP1, PRF1, TLR9, CCR7, NLRP12, TLR5, PTPRCv1, FCGR1A, BLR1, GNLY, RAB33A and NCAM1) was strongly associated with TB disease and these genes indeed play critical roles in the immune response against TB. Here, PRF1 is linked to tuberculosis.