In 341 non-neutropenic febrile episodes, both PCT and CRP levels discriminated bacteremia from non-bacteremia (PCT: 0.97 (0.27–5.61) ng/mL vs. 0.20 (0.17–0.24) ng/mL, P < 0.001; CRP: 146.1 (78.9–240.2) mg/L vs. 52.2 (46.4–62.0) mg/L, P < 0.001). Here, CRP is linked to bacterial infectious disease with sepsis.