ISG15 and nonpapillary renal cell carcinoma: As the values of certain factors increased (PLAU, RNASE2 and UCN levels and the risk score), the histological grade of ccRCC patients increased (all p < 0.05) (Figure 11A–11D), and as the values of other factors increased (PLAU, ISG15, IRF9, RNASE2 and UCN levels and the risk score), the pathological stage of ccRCC patients increased (all p < 0.05) (Figure 11E–11J).