CIS results in oocyte damage (Kim et al. 2013, Nguyen et al. 2019), with oocytes activating c-ABL and in turn the oocyte-specific homologue of p53, Tap63, that mediates the oocyte’s DNA damage response (Gonfloni et al. 2009, Gonfloni 2010, Bolcun-Filas et al. 2014, Rinaldi et al. 2017, Nguyen et al. 2018, Kim et al. 2019). Here, TP53 is linked to in situ carcinoma.