In a retrospective study involving 180 patients with prostate cancer, the authors revealed that elevated PTK-7 expression was significantly associated with lymph node metastases, seminal vesicle invasion, prostate cancer stage, the higher preoperative prostate-specific antigen, the higher Gleason score, angiolymphatic invasion, and biochemical recurrence (20). The gene discussed is KLK3; the disease is prostate carcinoma.