Relative UBE2L6 mRNA levels are shown as differences in Ct values as compared to mRNA levels for the housekeeping genes HMBS and ABL1. Expression was significantly lower in AML patient samples and HSC cells than in granulocytes, suggesting that increased expression may be important for the mature granulocyte phenotype (Mann–Whitney U‐test, ****P ≤ 0.0001) (Fig. 1A). The gene discussed is HMBS; the disease is acute myeloid leukemia.