UBE2L6 and acute myeloid leukemia: Using two cell line models of AML cell differentiation, we show that cells undergoing ATRA‐mediated neutrophil differentiation strongly induce UBE2L6. We show that shRNA depletion of UBE2L6 in leukemic cells impedes their ability to differentiate, reporting for the first time a functional importance for this enzyme in ATRA‐mediated leukemic cell differentiation.