Ubiquitin-specific protease 7 (USP7) promotes the growth of MYCN-amplified NB cell lines by inducing the deubiquitination and subsequent stabilization of MYCN [10], while the ubiquitin-ligase FBW7 promotes the proteasome-mediated MYCN degradation and leads to the opposite result [11]. This evidence concerns the gene MYCN and neuroblastoma.