In agreement with above hypothesis, genome-wide methylation analysis on 60 NB tumors using Illumina 450K methylation arrays revealed that TRIM36 is hypermethylated and has lower expression in aggressive NB tumors compared with less aggressive ones [71], indicating that down-regulated TRIM36 has a significant correlation with NB tumor pathogenesis and progression. The gene discussed is TRIM36; the disease is neuroblastoma.